上肢深静脉血栓

# 上肢深静脉血栓

# Upper Extremity Deep Venous Thrombosis

Areg Grigorian; Jeffry T. Nahmias.

Last Update: July 26, 2020.

# Continuing Education Activity

Researchers have extensively studied deep vein thrombosis (DVT) of the lower extremities. With the increased use of central venous catheters, cardiac pacemakers/defibrillators, and peripherally inserted central catheter (PICC) lines. DVTs in the upper extremities have become more commonplace and require a heightened index of suspicion from clinicians. Patients can be otherwise asymptomatic but commonly present with limb swelling. The most serious complication associated with any DVT, including upper extremity DVT, is a pulmonary embolus (PE). Recognition and appropriate intervention may prevent significant patient morbidity and mortality. This activity reviews the evaluation and management of deep venous thrombosis of the upper extremity and the role of interprofessional team members in collaborating to provide well-coordinated care and enhance patient outcomes.

Objectives:

Review the causes of upper extremity deep vein thrombosis.
Summarize the treatment of upper extremity deep vein thrombosis.
Describe the evaluation of a patient with suspected upper extremity deep vein thrombosis.
Outline the evaluation and management of deep venous thrombosis of the upper extremity and the role of interprofessional team members in collaborating to provide well-coordinated care and enhance patient outcomes.

# Introduction

Researchers have extensively studied deep vein thrombosis (DVT) of the lower extremities. With the increased use of central venous catheters, cardiac pacemakers/defibrillators, and peripherally inserted central catheter (PICC) lines. DVTs in the upper extremities have become more commonplace and require a heightened index of suspicion from clinicians. Patients can be otherwise asymptomatic but commonly present with limb swelling. The most serious complication associated with any DVT, including upper extremity DVT, is a pulmonary embolus (PE). Recognition and appropriate intervention may prevent significant patient morbidity and mortality.[1] (opens new window)[2] (opens new window)[3] (opens new window)[4] (opens new window)

# Etiology

Upper extremity DVT primarily involves brachial, axillary, and subclavian veins. The internal jugular veins and the more distal radial and ulnar veins are involved less frequently. There are 2 forms of upper extremity DVT: primary and secondary. The primary form is known as Paget-Schroetter syndrome (PSS) and typically occurs in the dominant arm of younger athletic patients involved in activities requiring excessive and repeated motion of the upper extremities such as wrestling, swimming, gymnastics, and sports involving repetitive ball throwing (i.e., football, baseball, and basketball). The secondary form occurs most commonly in patients with central venous catheterization or patients with malignancy.[5] (opens new window)[6] (opens new window)[7] (opens new window)[8] (opens new window)

# Epidemiology

Upper extremity DVTs currently comprise 5% to 10% of all DVTs with the incidence rising annually. The majority of patients have a central line, while PSS accounts for only 10% to 20% of cases. The rate of upper extremity DVT in all patients with central catheterization is between 14% to 23%. PE occurs in up to 6% of DVTs affecting the upper extremities compared to 15% to 30% in the lower extremities. Post-thrombotic syndrome occurs in less than 5% of DVTs in the upper extremities compared to greater than 50% in the lower extremities.

# Pathophysiology

In the primary form (PSS), repeated motions of the upper extremity result in hypertrophy of the scalene muscles, which can compromise the neurovascular bundle as it exits the thorax between the cervical rib and surrounding musculature. Repeated compression of the subclavian vein results in venous stasis as well as perivenous microtrauma activating the intrinsic coagulation pathway with eventual thrombosis. In the secondary form, catheterization disrupts the endothelial lining and also activates a similar coagulation cascade. Additionally, congenital and acquired cases of coagulation disorders such as Factor V Leiden mutation or malignancy also increase the risk for upper extremity DVT.

# History and Physical

A focused history and physical exam often reveal clinical findings suggestive of upper extremity DVT, which can then be confirmed with subsequent imaging studies. The majority of patients present only with limb swelling and arm discomfort. The onset and duration of limb swelling along with any previous history of DVT should be obtained. Patients may also complain of arm heaviness. The physical exam may also reveal limb erythema with visible veins across the chest and upper extremity (Urschel’s sign). Personal and family history of hypercoagulable disorders are relevant as well as if any prior central venous catheterization has been attempted. In the primary form (PSS), patients will present with a sudden onset of severe limb pain and swelling often in the dominant arm. These patients are younger and often participate in activities requiring excessive and repeated motions of the upper extremity (e.g., baseball pitcher). In all patients, distal pulses should be assessed. Limbs appearing pale, cool and mottled are at risk of ischemia. Any motor or sensory deficit should be noted, as these require emergency intervention.

# Evaluation

A focused history and physical exam can reveal findings suspicious for DVT in the upper extremity. The best way to confirm a diagnosis is with compression duplex ultrasonography. This test has a sensitivity of 97% and specificity of 96% for the determination of DVT in the upper extremity and is often the test of choice. However, several other imaging modalities including magnetic resonance and computed tomographic venography are superior to ultrasonography, but their clinical use may be limited by high costs, radiation exposure, and/or availability. The sensitivity of compression duplex ultrasonography is 97%, which is lower than magnetic resonance venography (100%). However, it is non-invasive, less expensive and widely available, thus remains the test of choice to diagnose upper extremity DVT. Laboratory studies are not required for diagnosis, but a coagulation assay can be ordered in patients suspected of having a hypercoagulable condition. In patients with a low suspicion of upper extremity DVT, a d-dimer test can help rule it out. A patient with upper extremity DVT complicated by PE may present with chest pain and shortness of breath. ECG should be performed because it will most commonly demonstrate sinus tachycardia.[9] (opens new window)[10] (opens new window)[11] (opens new window)

# Treatment / Management

The treatment of upper extremity DVTs depends on the clinical presentation. The majority of patients present with limb swelling in the setting of central venous catheterization. The American College of Chest Physicians recommends that the clinician first determine the necessity of the line. If it is required (e.g., total peripheral nutrition), it should remain in place, and the patient should be started on anticoagulation therapy. If the line is not needed, it should be removed but only after completion of 3 to 5 days of anticoagulation therapy. In the hospital, patients can be bridged to warfarin with unfractionated heparin. Patients should continue on warfarin for 3 to 6 months after diagnosis. The role of novel oral anticoagulant agents (e.g., dabigatran) is under current investigation, but recent data from the Swedish national anticoagulation registry, (National Quality Registry for Atrial Fibrillation and Anticoagulation [AuriculA]) suggests that these drugs can be used for the treatment of upper extremity DVT with acceptable efficacy and safety.[12] (opens new window)[13] (opens new window)

治疗 / 处理

依据临床表现对上肢深静脉血栓进行治疗。留置中心静脉导管的多数患者有肢体肿胀。美国胸科医师协会推荐医师要首先判断导管的必要性。如果需要留置（如，全肠外营养），则留在原位，并开始抗凝治疗。如果不再需要，抗凝治疗 3-5 天后拔除。患者在院内从普通肝素桥接至华法令。华法令一直服用至诊断后的 3-6 个月。新型口服抗凝剂的作用正在进行研究，不过瑞士全国范围村内的房颤与抗凝国家注册登记研究（AuriculA）表明此类药物可以用于上肢深静脉血栓的治疗，有效性和安全性能够接受。

腋静脉创伤性血栓形成综合征（佩 - 施二氏综合征，Paget-Schroetter syndrome，PSS) 时，不同于急性血栓的典型治疗。照此，患者出现明显的疼痛和肿胀时需要静脉内导管直接溶栓。这通常能解决疼痛和肿胀，但不能解决潜在病因。因此 PSS 患者可能需要急诊手术治疗，去除第一肋骨，给胸廓出口增加额外空间，放置进一步压迫神经血管束。

# Differential Diagnosis

Several clinical states may mimic limb swelling seen in upper extremity DVT. For instance, localized infection with cellulitis may result in venous congestion, which may appear similar to a DVT. Patients with cellulitis may have a nidus for infection (i.e., cut or insect bite) along with surrounding erythema and pain. Necrotizing fasciitis may have overlying bullae along with systemic signs of infection such as fever, leukocytosis, elevated sedimentation rate and C-reactive protein with hyponatremia. Necrotizing fasciitis requires prompt diagnosis and early surgical debridement to prevent mortality and limb loss. Superficial thrombophlebitis involves an inflamed superficial vein in the upper extremity. This often resolves with limb elevation, warm compresses, and non-steroidal anti-inflammatory agents. Suppurative or septic superficial thrombophlebitis is associated with significant morbidity and mortality requiring prompt and aggressive intervention that includes excision of the infected vein. This occurs more commonly in patients with significant burns or intravenous drug abuse. Lymphedema can present with limb swelling but most commonly in the upper extremity occurs after a procedure such as axillary lymph node dissection.

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# Prognosis

The prognosis differs between primary and secondary forms. Patients with the primary form (PSS) of upper extremity DVT are typically young and healthy, while those with secondary forms are often previously hospitalized and may have significant co-morbidities such as cancer. In a large database study, overall 3-month mortality in patients with DVT in the upper extremity was 11%. In a sub-group analysis of patients with cancer, the mortality rate was as high as 28%. Complications such as PE and post-thrombotic syndrome can also occur. PE occurs in up to 6% of cases and occurs most often in secondary forms of upper extremity DVT. Post-thrombotic syndrome occurs in less than 5% of upper extremity DVT and can result in persistent limb swelling, pain, and heaviness. However, in patients with PSS, the post-thrombotic syndrome can occur in as high as 45% of cases. If this continues untreated, it can result in skin discoloration and collateralization. Investigations are underway to determine if compression therapy may help prevent and/or treat the post-thrombotic syndrome.

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# Pearls and Other Issues

There continues to be controversy regarding prophylactic anticoagulation therapy in cancer patients with central venous catheterization. Several randomized controlled trials have not shown benefit in this patient population receiving warfarin or low molecular weight heparin.

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# Enhancing Healthcare Team Outcomes

The management of upper extremity DVT is by an interprofessional team that includes a radiologist, oncologist, nephrologist, hematologist, an internist and a vascular surgeon. The treatment of upper extremity DVTs depends on the clinical presentation. The majority of patients present with limb swelling in the setting of central venous catheterization. The American College of Chest Physicians recommends that the clinician first determine the necessity of the line. If it is required (e.g., total peripheral nutrition), it should remain in place, and the patient should be started on anticoagulation therapy. If the line is not needed, it should be removed but only after completion of 3 to 5 days of anticoagulation therapy. In the hospital, patients can be bridged to warfarin with unfractionated heparin; clinicians would do well to consult the pharmacist for proper bridging and continued anticoagulation. Patients should continue on warfarin for 3 to 6 months after diagnosis, with vigilant monitoring by the nurse and clinician.

In the case of PSS, the treatment course differs as it typically involves acute thrombosis. As such, patients develop significant pain and swelling requiring intravenous catheter-directed thrombolysis. This often resolves pain and swelling but does not treat the underlying etiology. Patients with PSS will, therefore, require urgent surgical intervention for first rib removal. This provides additional space in the thoracic outlet to prevent future compression of the neurovascular bundle. Post-thrombotic phlebitis is known to occur in some patients and they may need to wear compression garments and/or undertake physical therapy. Here again, nursing staff can help the clinician with monitoring and serve as a bridge between therapists and the clinician.[14] (opens new window)[15] (opens new window) These examples of interprofessional coordination can help drive better outcomes. [Level 5]

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# Continuing Education / Review Questions

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# References

Chen AWY, Oraii Yazdani K, Candilio L. Upper Limb Deep Vein Thrombosis: A Case Report of an Increasingly Common Condition. J Tehran Heart Cent. 2018 Apr;13(2):73-75. [PMC free article (opens new window)] [PubMed (opens new window)]
Lim W, Le Gal G, Bates SM, Righini M, Haramati LB, Lang E, Kline JA, Chasteen S, Snyder M, Patel P, Bhatt M, Patel P, Braun C, Begum H, Wiercioch W, Schünemann HJ, Mustafa RA. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018 Nov 27;2(22):3226-3256. [PMC free article (opens new window)] [PubMed (opens new window)]
Samuelson Bannow BR, Lee AYY, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review. Res Pract Thromb Haemost. 2018 Oct;2(4):664-669. [PMC free article (opens new window)] [PubMed (opens new window)]
Watanabe C, Ichiba T, Naito H. Left subclavian and right femoral vein thrombosis in a pregnant patient with antithrombin deficiency. J Cardiol Cases. 2018 Oct;18(4):149-151. [PMC free article (opens new window)] [PubMed (opens new window)]
Drouin L, Pistorius MA, Lafforgue A, N'Gohou C, Richard A, Connault J, Espitia O. [Upper-extremity venous thrombosis: A retrospective study about 160 cases]. Rev Med Interne. 2019 Jan;40(1):9-15. [PubMed (opens new window)]
Dronkers CEA, Klok FA, van Haren GR, Gleditsch J, Westerlund E, Huisman MV, Kroft LJM. Diagnosing upper extremity deep vein thrombosis with non-contrast-enhanced Magnetic Resonance Direct Thrombus Imaging: A pilot study. Thromb Res. 2018 Mar;163:47-50. [PubMed (opens new window)]
Holzhauser L, Imamura T, Nayak HM, Sarswat N, Kim G, Raikhelkar J, Kalantari S, Patel A, Onsager D, Song T, Ota T, Jeevanandam V, Sayer G, Uriel N. Consequences of Retained Defibrillator and Pacemaker Leads After Heart Transplantation-An Underrecognized Problem. J Card Fail. 2018 Feb;24(2):101-108. [PMC free article (opens new window)] [PubMed (opens new window)]
Bishop M, Astolfi M, Padegimas E, DeLuca P, Hammoud S. Venous Thromboembolism Within Professional American Sport Leagues. Orthop J Sports Med. 2017 Dec;5(12):2325967117745530. [PMC free article (opens new window)] [PubMed (opens new window)]
Wells PS, Ihaddadene R, Reilly A, Forgie MA. Diagnosis of Venous Thromboembolism: 20 Years of Progress. Ann Intern Med. 2018 Jan 16;168(2):131-140. [PubMed (opens new window)]
McLendon K, Goyal A, Bansal P, Attia M. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Apr 29, 2020. Deep Venous Thrombosis Risk Factors. [PubMed (opens new window)]
Adelborg K, Horváth-Puhó E, Sundbøll J, Prandoni P, Ording A, Sørensen HT. Risk and prognosis of cancer after upper-extremity deep venous thrombosis: A population-based cohort study. Thromb Res. 2018 Jan;161:106-110. [PubMed (opens new window)]
Chopra V, Kaatz S, Conlon A, Paje D, Grant PJ, Rogers MAM, Bernstein SJ, Saint S, Flanders SA. The Michigan Risk Score to predict peripherally inserted central catheter-associated thrombosis. J Thromb Haemost. 2017 Oct;15(10):1951-1962. [PubMed (opens new window)]
Montiel FS, Ghazvinian R, Gottsäter A, Elf J. Treatment with direct oral anticoagulants in patients with upper extremity deep vein thrombosis. Thromb J. 2017;15:26. [PMC free article (opens new window)] [PubMed (opens new window)]
Elboudwarej O, Patel JK, Liou F, Rafiei M, Osborne A, Chai W, Kittleson M, Czer L, Stern L, Esmailian F, Kobashigawa JA. Risk of deep vein thrombosis and pulmonary embolism after heart transplantation: clinical outcomes comparing upper extremity deep vein thrombosis and lower extremity deep vein thrombosis. Clin Transplant. 2015 Jul;29(7):629-35. [PubMed (opens new window)]
Lee JA, Zierler BK, Zierler RE. The risk factors and clinical outcomes of upper extremity deep vein thrombosis. Vasc Endovascular Surg. 2012 Feb;46(2):139-44. [PubMed (opens new window)]

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上次更新: 2022/04/25, 11:11:51

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